New research suggests that people who discontinue blockbuster weight-loss injections like semaglutide or tirzepatide may regain lost weight at a significantly accelerated pace than those who stop traditional lifestyle plans.
Research printed in a major medical journal shows that while obese individuals frequently drop about a fifth of their body weight while on the medication, the weight comes back at an average rate of 0.8 kg per month once they quit.
"Individuals buying such treatments should be cognizant of the potential of fast rebound weight gain when the therapy ends," warns lead investigator Dr. Susan Jebb.
That rate of recovery suggests a reversion to original mass in about 18 months.
Weighing Treatments
The research, which examined 37 of trials involving thousands of patients, contrasted the results of the injectable medications with older methods.
Scientists emphasize that people who lose weight through diet and exercise usually experience a more gradual weight regain—around 100 grams monthly—after stopping.
Understanding the Fast Regain
Experts believe the mode of action of the jabs accounts for the heightened rebound.
These medications imitate a natural hormone called GLP-1, which helps regulate feelings of fullness.
"Artificially providing the hormone concentrations far above than normal might result in the system to generate a reduced amount of its endogenous hormone, and could lessen responsiveness to its actions," said Dr. Adam Collins, a nutrition expert.
"Withdrawal of this medication means appetite is uncontrolled, making overeating far more likely."
An Ongoing Issue?
Medical guidelines recommend the injections for people with weight-linked medical conditions, accompanied by recommended diet and exercise modifications.
Many experts argue that, considering the significant potential of relapse, the therapy is often ongoing.
This perspective is supported by drug manufacturers, who note that the findings "highlight the chronic character of obesity," akin to managing diseases like high blood pressure.
User Experiences
People who have discontinued the medication report a sudden resurgence of cravings.
"It was like a trigger that goes on and you're instantly ravenous," recalled a patient.
This challenge is worsened if patients have not developed sustainable dietary or behavioural changes during treatment.
Widespread Adoption
Figures indicate that a significant number of people in the UK have used weight-loss jabs in the past year, with demand being substantial.
- Adoption is higher among women compared to men.
- The 40s and 50s age group shows the highest level of interest.
- Many access the drugs through private prescriptions rather than the NHS.
Ultimately, experts caution that while the jabs are effective tools for weight loss, they are not a magic fix and maintained weight loss hinges on integrated behavioural support.
